Common variants of cGKII/PRKG2 are not associated with gout susceptibility

Masayuki Sakiyama; Hirotaka Matsuo; Toshinori Chiba; Akiyoshi Nakayama; Takahiro Nakamura; Seiko Shimizu; Emi Morita; Nana Fukuda; Hiroshi Nakashima; Yutaka Sakurai; Kimiyoshi Ichida; Toru Shimizu; Nariyoshi Shinomiya

doi:10.3899/jrheum.131548

Common variants of cGKII/PRKG2 are not associated with gout susceptibility

J Rheumatol. 2014 Jul;41(7):1395-7. doi: 10.3899/jrheum.131548. Epub 2014 Jun 1.

Affiliations

¹ From the Department of Integrative Physiology and Bio-Nano Medicine, Department of Dermatology, Laboratory for Mathematics, and Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya; Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo; Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo; and Midorigaoka Hospital, Takatsuki, Japan.M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical College; H. Matsuo, MD, PhD; T. Chiba, MD; A. Nakayama, MD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College; T. Nakamura, PhD, Laboratory for Mathematics, National Defense Medical College; S. Shimizu, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College; E. Morita, MD, PhD; N. Fukuda, BHE, Department of Preventive Medicine, Nagoya University Graduate School of Medicine; H. Nakashima, MD, PhD; Y. Sakurai, MD, PhD, Department of Preventive Medicine and Public Health, National Defense Medical College; K. Ichida, MD, PhD, Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences; Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine; T. Shimizu, MD, PhD, Midorigaoka Hospital; N. Shinomiya, MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College.
² From the Department of Integrative Physiology and Bio-Nano Medicine, Department of Dermatology, Laboratory for Mathematics, and Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya; Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo; Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo; and Midorigaoka Hospital, Takatsuki, Japan.M. Sakiyama, MD, Department of Integrative Physiology and Bio-Nano Medicine, and Department of Dermatology, National Defense Medical College; H. Matsuo, MD, PhD; T. Chiba, MD; A. Nakayama, MD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College; T. Nakamura, PhD, Laboratory for Mathematics, National Defense Medical College; S. Shimizu, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College; E. Morita, MD, PhD; N. Fukuda, BHE, Department of Preventive Medicine, Nagoya University Graduate School of Medicine; H. Nakashima, MD, PhD; Y. Sakurai, MD, PhD, Department of Preventive Medicine and Public Health, National Defense Medical College; K. Ichida, MD, PhD, Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences; Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine; T. Shimizu, MD, PhD, Midorigaoka Hospital; N. Shinomiya, MD, PhD, Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College. hmatsuo@ndmc.ac.jp.

PMID: 24882840
DOI: 10.3899/jrheum.131548

Abstract

Objective: Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population.

Methods: Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls.

Results: cGKII variants have no association with gout.

Conclusion: Our replication study suggests that cGKII is not involved in gout susceptibility.

Keywords: GOUTY ARTHRITIS; HYPERURICEMIA; SINGLE NUCLEOTIDE POLYMORPHISMS; URATE; URIC ACID.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Asian People / genetics*
Case-Control Studies
Cyclic GMP-Dependent Protein Kinase Type II / genetics*
Genetic Predisposition to Disease*
Genotype
Gout / genetics*
Humans
Japan
Male
Middle Aged

Substances

Cyclic GMP-Dependent Protein Kinase Type II
PRKG2 protein, human